Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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Computer Simulation of Angiotensin II Binding to Its Receptor for de novo Lead Search

  • Kim, Dooil (Department of Chemistry, Ilanyang University) ;
  • Youngdo Won (Department of Chemistry, Ilanyang University)
  • Published : 1996.07.01
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Abstract

A working molecular model of the angiotensin II type 1 receptor is built based on the seven transmembrane helix structure of the recently refined bacteriorhodopsin atomic coordinates. A multiple copy simultaneous search (MCSS) method is used to search the pharmacophore of angiotensin on the surface of the receptor. Multiple copies of amino acid fragments and organic functional groups are scattered around the possible binding site and the time dependent. (omitted)

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