Proceedings of the Korean Biophysical Society Conference (한국생물물리학회:학술대회논문집)

The Korean Biophysical Society (한국생물물리학회)
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NMR STRUCTURE DETERMINATION OF A NOVEL CONOTOXIN, [Pro 7,13] $\alpha$A-conotoxin $P_{IVA}$

  • Han, Kyou-Hoon (Biomolecular Structure Research Unit, KRIBB/KIST) ;
  • Hwang, Kae-Jung (Biomolecular Structure Research Unit, KRIBB/KIS) ;
  • Kim, Seung-Moak (Biomolecular Structure Research Unit, KRIBB/KIS) ;
  • Kim, Soo-Kyung (Biomolecular Structure Research Unit, KRIBB/KIS) ;
  • William R. Gray (Dept. of Biology, Univ. of Uta) ;
  • Shon, Ki-Joon (Dept. of Biology, Univ. of Utah, Dept. of Physiology and Biophysics, Case Western Reserve Uni) ;
  • Jean Rivier (Clayton Lab. for Peptide Biology, The Salk Institut) ;
  • Baldomero M. Olivera (Dept. of Biology, Univ. of Utah)
  • Published : 1996.07.01
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Abstract

High-resolution solution conformation of a novel conotoxin, [Pro 7,13] $\alpha$A-conotoxin $P_{IVA}$, GCCGSYPNAACHPCSCKDROSYCGQ-N $H_2$, has been determined by two-dimensional $^1$H nmr methods in combination with distance geometry calculation to rmsd values of 0.90 $\AA$ and 1.16 $\AA$ for the backbone and heavy atoms, respectively. Total of 324 NOE-derived interproton distance restraints including 33 long-range NOE restraints a well as 11 $\Phi$ and 7 $\chi$$^1$ torsion angle restraints were used for computation of structures. (omitted)d)

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