Advantage and Disadvantage of Autoradiography - Current topics of Autoradiography in New Drug Development Studies of Japan

The 116 annual meeting of the pharmaceutical Society of Japan was held in Kanazawa from March 27 to 29 in 1996. Our presentation will be concerned to a few topics in this meeting. Recently not only pharmaco and toxico kinetic studies but also pharmaco and toxico dynamic studies are beginning to be worthy of notice. This is quite reasonable. because the blood concentration time curves of a parent compound must be useful, but it is no more than a cross section for pharmaco and toxico dynamics in many organs and tissues as main reaction site for drug metabolism.