Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Exofocal Damage to the Substantia Nigra by Transient Middle Cerebral Artery Occlusion in Rats

  • Jin, Changbae (Doping Control Center, Korea Institute of Science and Technology) ;
  • Yanai, Kazuhiko (Dept. of Pharmacology I, Tohoku University School of Medicine) ;
  • Araki, Tsutomu (Dept. of Neurology, Tohoku University School of Medicine) ;
  • Watanabe, Takehiko (Dept. of Pharmacology I, Tohoku University School of Medicine)
  • Published : 1996.04.01
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Abstract

The present study examined chronic effects of transient focal cerebral ischemia on the substantia nigra, a remote exofocal area, using immunohistochenmical and receptor autoradiographic techniques. Transient focal cerebral ischemia was induced by middle cerebral artery (MCA) occlusion for 60 or 90 min followed by reperfusion using silicone-coated 4-0 nylon monofilament in male Wistar rats. After 1- or 2-week reperfusion following transient MCA occlusion, there were partial losses of tyrosine hydroxylase-immunoreactive dopaminergic neurons, incieases in glial fibrillary acidic protein-immunoreactive cells (gliosis), decreases in [$^3$H]YM-09151-2 binding for dopamine D$_2$ receptors, and marked atrophy in the ipsilateral substantia nigra. The precise mechanism(s) of exofocal damage to the substantia nigra is remained to be elucidated.

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