한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1996년도 춘계학술대회
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- Pages.211-211
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- 1996
The Effects of Lead Exposure on Glutamatergic Nervous System in Rat Cerebellar Cells
- Yi, Eun-Young (College of Pharmacy, Chonnam National University) ;
- Ma, Young (College of Pharmacy, Chonnam National University) ;
- Choi, Woo-Joung (College of Pharmacy, Chonnam National University) ;
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Lim, Dong-Koo
(College of Pharmacy, Chonnam National University)
- 발행 : 1996.04.01
초록
Changes in glutamate release and uptake on cerebellar cells after the chronic exposure to lead were investigated. Rats were received 0.25% lead acetate in drinking water from the beginning of the pregnancy. The control group was given 0.125% sodium acetate in drinking water. The cerebellar cells from 7 or 8 day-old pups were cultured. Amino acid release from cerebellar granule cells and the glutamate uptake into cerebellar glial cells were measured using HPLC-ECD. Basal glutamate release and NMDA-induced glutamate release didn't show significant difference. However, the other amino acids in the granule cells obtained from lead exposed pups were less released than the control after the stimulation by NMDA (50
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