Proceedings of the Korea Society of Environmental Toocicology Conference (한국환경독성학회:학술대회논문집)

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
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FUMONISIN $B_1$IN DEVELOPING RATS ALTERS BRAIN SPHINGANINE LEVELS AND MYELINATTON.

  • Kwon, Oh-Seung (Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences) ;
  • Schmued, Laurence. C. (Division of Neurotoxicology, National Center for Toxicological Research, Pood and Drug Administration) ;
  • William Slikker, JR (Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Division of Neurotoxicology, National Center for Toxicological Research, Pood and Drug Administration)
  • Published : 1996.12.01
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Abstract

KWON, O. S. SCHMUED, L. C. and LSIKKER, W. JR. Neurotoxiciligy. objectives of this study were to test the hypothesis that fumonisin $B_1$ ($FB_1$) alters sphinganine (Sa) levels and myelin synthesis in the central nervous system of developing rats. $FB_1$ (subcutaneous, 0. 4 or 0. 8 mg/kg/day) from postnatal days (PND) 3 to PND 12 resulted in a significantly increased in the brain of rats given 0. 8 mg $FB_1$/kg/day. To confirm the effect of limited nutrition on changes in the Sa levels and myelinogenesis, rats given 0.8mg $FB_1$/kg/day or treated by limited nutrition (temporary removal from dam during postnatal period) were compared to those in saline controls. Sa levels and Sa/So ratios were compared to those in saline in the 0.8 $FB_1$-treated, 3'-phosphohydrolase (CNP) activities were decreased significantly in both nutritionally limited and $FB_1$-exposed rats. These data indicate that sphingolipid metabolism in the central nervous system of develiping rats is vulnerable to $FB_1$ exposure. The hypomyelination associated with $FB_1$-treatment may be mediated by limited nutrition.

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