Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1995.04a
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- Pages.110-110
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- 1995
Dose-dependent antifibrotic effect of G009 on experimental hepatic cirrhosis
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Park, Eun-Jeon
(College of Pharmacy, Wonkwang University)
;
- Kim, Su-Ung (Il-Yang Pharm. Co.) ;
- Lee, Seung-Yong (Il-Yang Pharm. Co.) ;
- Kim, Jaebaek (College of Pharmacy, Wonkwang University) ;
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Sohn, Dong-Hwan
(College of Pharmacy, Wonkwang University)
- Published : 1995.04.01
Abstract
This study was carried out to investigate the dose dependent antifibrotic effects of G009, the water-soluble fraction of polysaccharide extracted from Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 0.5, 2, 5 or 10mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents, and light microscopical histology.
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