한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1995년도 춘계학술대회
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- Pages.106-106
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- 1995
General Pharmacology of G009, a Polysaccharide Isolated from Ganoderma lucidum IY 009
- Kim, Su-Ung (Central Research Laboratory, II Yang Pharmaceutical Company, Ltd) ;
- Lee, Seung-Yong (Central Research Laboratory, II Yang Pharmaceutical Company, Ltd) ;
- Lee, Seung-Mok (Central Research Laboratory, II Yang Pharmaceutical Company, Ltd) ;
- Jeong, Hoon (Central Research Laboratory, II Yang Pharmaceutical Company, Ltd) ;
- Hyun, Ik-Sang (Central Research Laboratory, II Yang Pharmaceutical Company, Ltd) ;
- Lee, June-Woo (Central Research Laboratory, II Yang Pharmaceutical Company, Ltd) ;
- Han, Man-Deuk (Central Research Laboratory, II Yang Pharmaceutical Company, Ltd) ;
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Lee, Eun-Bang
(Natural Products Research Institute, Seoul National University) ;
- Cheon, Seon-Ah (Natural Products Research Institute, Seoul National University) ;
- Kim, Sang-Mee (Natural Products Research Institute, Seoul National University) ;
- Kim, Kyung-Ran (Natural Products Research Institute, Seoul National University)
- 발행 : 1995.04.01
초록
A polysaccharide, G009, isolated from Ganoderma lucidum IY009 subjected to investigating on general pharmacology. This material at the large oral doses of 1000 and 2000mg/kg in mice did neither exhibit any abnormal behaviors nor effects on central nervous system. It also had no influences on hexobarbital-induced sleeping time, rotarod test and spontaneous activity test at each oral dose of 1000mg/kg in mice. No effects on the body temperature and on acetic acid induced writhing syndrome in mice were observed with its oral administration at 1000mg/kg, and the convulsions induced by strychnine and pentetrazole were not inhibited at its oral doses of 1000mg/kg in mice. The solution of G009 as given intravenously at the doses of 30 and 60mg/kg in rabbit had no influences on blood pressure and respiration rates and depth. In isolated organs of rat uterus and fundus muscles and guinea-pig ileum and trachea, it did not show any contraction or relaxation at the concentration of 2
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