Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effects of Ginseng Total Saponin on Morphine-induced immunesuppression

  • Lee, S. Y. (College of Pharmacy, Chonnam National University) ;
  • Kim, A. Y. (College of Pharmacy, Chonnam National University) ;
  • Kim, Y. R. (College of Pharmacy, Chonnam National University) ;
  • G. S. Yoo (College of Pharmacy, Chonnam National University) ;
  • D. K. Lim (College of Pharmacy, Chonnam National University) ;
  • K. W. Oh (College of Pharmacy, Chungbuk National University) ;
  • Kim, K. M. (College of Pharmacy, Chonnam National University)
  • Published : 1995.04.01
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Abstract

Morphine produces wide-spread immunesuppression, such as lymphokine production, phagocytic activity, natural killer cell activity, cell proliferation, and cell-mediated immunity. On the other hand, one of the representative pharmacological act ions of Panax ginseng is immune enhancement. In this study, we investigated the effects of ginseng total sponin (GTS), and Adaptagen (trade name of ginseng product) on morphine-induced immunesuppression. Morphine hydrochloride (10 mg/kg, sc), GTS (400 mg/kg, oral), Adaptagen (400 mg/kg, oral ) were administered to mice for 14 consecutive days.

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