Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Effects of Ginseng preparation on the central dopaminergic nervous systems in AF64A- induced amnestic rats.

  • Lim, Dong-Koo (College of Pharmacy, Chonnam National University) ;
  • S. M. Wee (College of Pharmacy, Chonnam National University) ;
  • Kim, K. M. (College of Pharmacy, Chonnam National University) ;
  • K. W. Oh (College of Pharmacy, CnungBuk National University) ;
  • K. S. Yoo (College of Pharmacy, Chonnam National University)
  • Published : 1995.04.01
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Abstract

The effects of ginseng prepation, Adaptagen$\^$R/ (AD), on the central dopaminergic nervous system in the learning-impaired rats were studied. The learning impaired rats were rendered by the intracerebroventricular infusion of ethylcholine aziridium (AF64A), 3 nmol/each side. Three days after the infusion of AF64A, AD were orally intubated daily for five days, 200 mg/kg. The control groups were intubated with distilled water. Twenty four hours after the last intubation, The changes in the specific bindings of dopamine receptors, the concentrations of dopamine (DA) and metabolites, The activities of tyrosine hydrosylase (TH) and monoamine oxidase (MAO) were analyzed using receptor radiography, HPLC-ECD and the methods in enzyme-assays, respectively.

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