Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1995.04a
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- Pages.66-66
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- 1995
F93-A: A Inhibitor of Farnesyl Protein Transferase from Aspergillus fumigatus KL93
- Kwon, Byoung-Mog (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Lee, Seung-Ho (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Jeong, Tae-Sook (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Kim, Sung-Uk (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Son, Kwang-Hee (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Park, Diol (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Kim, Young-Kook (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Nam, Ji-Youn (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Bok, Song-Hae (Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST)
- Published : 1995.04.01
Abstract
Mutated forms of the ras oncogenes are associated with about 30% of human tumors. The ras genes encode 21KDa proteins, called p21 or Ras, that are associated with the plasma membrane. FPTase is a dimeric enzyme that catalyses the transfer of the farnesyl group from farnesyl pyrophosphate onto cysteine 186 at the C-terminus of the Ras protein. This is mandatory process for triggering ras oncogene toward tumor formation. Therefore, selective inhibitors of FPTase have the potential to be used as antitumorgenic agents.
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