Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1995.04a
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- Pages.65-65
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- 1995
F1064m: New Inhibitor of Cholesteryl Ester Transfer Protein (CETP), Isolated from Gliocladium virens F1064
- Kwon, Byoung-Mog (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Cho, Joung-Suk (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Jeong, Tae-Sook (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Kim, Sung-Uk (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Son, Kwang-Hee (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Kim, Young-Kook (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Nam, Ji-Youn (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Han, Kyu-Hoon (NMR Lab. Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Bok, Song-Hae (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST)
- Published : 1995.04.01
Abstract
Cholesteryl Ester Transfer Protein(CETP), a hydrophobic glycoprotein with molecular mass 74KDa, is a lipid transfer protein found in plasma which mediates the transfer of cholesterol ester and triglyceride between high-density lipoprotein (HDL) and other lipoproteins, therefore, it might influence HDL levels. The lipoprotein profile associated with human CETP deficiency (that are two Japanese families, high HDL and low LDL) has low atherogenic potential, raising the possibility that CETP inhibitors can be used as antiatherosclerotic drugs.
Keywords