Solandelactone G: A Novel Inhibitor of Farnesyl Protein Transferase (FPTase), Isolated from the Hydroid Solanderia secunda

  • Jongheon Shin (Marine Natural Products Chemistry Lab., Korea Ocean Research & Development Institute) ;
  • Youngwan Seo (Marine Natural Products Chemistry Lab., Korea Ocean Research & Development Institute) ;
  • Park, Jung-Rae (Marine Natural Products Chemistry Lab., Korea Ocean Research & Development Institute) ;
  • Kwon, Byoung-Mog (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Nam, Ji-Youn (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Jeong, Tae-Sook (BiopBioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
  • Bok, Song-Hae (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST)
  • Published : 1995.04.01

Abstract

Farnesyl Protein Transferase (FPTase) catalyses a post-translational modification of Ras that is obligatory for the cell transforming activity of this oncogene protein. The screening of natural products to identify inhibitors of this enzyme as a potential anticancer agents, has led to the isolation of a novel lactone, from the hydroid Solanderia secunda. Solandelactone G has been isolated from the hydroid Solanderia secunda collected along the offshore of Jaejudo and Keomunde. The structure of the compound has been determined as cyclopropane containing C$\_$22/ fatty acid lactone on the basis of the combined spectral and chemical methods

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