Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 1995.04a
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- Pages.63-63
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- 1995
Solandelactone G: A Novel Inhibitor of Farnesyl Protein Transferase (FPTase), Isolated from the Hydroid Solanderia secunda
- Jongheon Shin (Marine Natural Products Chemistry Lab., Korea Ocean Research & Development Institute) ;
- Youngwan Seo (Marine Natural Products Chemistry Lab., Korea Ocean Research & Development Institute) ;
- Park, Jung-Rae (Marine Natural Products Chemistry Lab., Korea Ocean Research & Development Institute) ;
- Kwon, Byoung-Mog (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Nam, Ji-Youn (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Jeong, Tae-Sook (BiopBioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST) ;
- Bok, Song-Hae (Bioproducts RG, Korea Research Institute of Bioscience & Biotechnology, KIST)
- Published : 1995.04.01
Abstract
Farnesyl Protein Transferase (FPTase) catalyses a post-translational modification of Ras that is obligatory for the cell transforming activity of this oncogene protein. The screening of natural products to identify inhibitors of this enzyme as a potential anticancer agents, has led to the isolation of a novel lactone, from the hydroid Solanderia secunda. Solandelactone G has been isolated from the hydroid Solanderia secunda collected along the offshore of Jaejudo and Keomunde. The structure of the compound has been determined as cyclopropane containing C
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