Interval estimate of physiological fluctuation of peak latency of ERP waveform based on a limited number of single sweep records

  • Nishida, Shigeto (Department of Communication and Computer Engineering, Fukuoka Institute of Technology) ;
  • Nakamura, Masatoshi (Department of Electrical Engineering, Saga University) ;
  • Suwazono, Shugo (Third Department of Internal Medicine, Kagoshima University School of Medicine) ;
  • Honda, Manabu (Department of Brain Pathophysiology, Kyoto University Faculty of Medicine) ;
  • Nagamine, Takashi (Department of Brain Pathophysiology, Kyoto University Faculty of Medicine) ;
  • Shibasaki, Hiroshi (Department of Brain Pathophysiology, Kyoto University Faculty of Medicine)
  • Published : 1994.10.01

Abstract

In the single sweep record of event-related potential (ERP), the peak latency of P300, which is one of the most prominent positive peaks in the ERP record, might fluctuate according to the recording conditions. The fluctuation of the peak latency (measurement fluctuation) is the summation of the fluctuation caused by physiological factor (physiological fluctuation) and one by noise of background EEG (noise fluctuation). We propsed a method for estimating the interval of the physiological fluctuation based on a limited number of single sweep records. The noise fluctuation was estimated by using the relationship between the signal-to-noise (SN) ratio and the noise fluctuation based on the P300 model and the background EEG model. The interval estimate of the physiological fluctuation were obtained by subtracting the interval estimate of the noise fluctuation from that of the measurement fluctuation. The proposed method was tested by using simulation data of ERP and applied to actual ERP and data of normal subjects, and gave satisfactory results.

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