대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference)

대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지

생체실험을 통한 좌심실보조기의 평가

Evaluation of Left Ventricular Assist Device through In Vivo Experiments

  • 박성근 (서울대학교 의과대학 의공학교실) ;
  • 원용순 (서울대학교 의과대학 흉부외과학교실) ;
  • 정필섭 (서울대학교 의과대학 이비인후과학교실) ;
  • 최진욱 (서울대학교 의과대학 의공학교실) ;
  • 김인영 (서울대학교 의과대학 의공학교실) ;
  • 이규백 (서울대학교 의과대학 의공학교실) ;
  • 민병구 (서울대학교 의과대학 의공학교실)
  • Park, Seong-Keun (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Won, Yong-Soon (Dept. of Thoracic Surgery, College of Medicine, Seoul National University) ;
  • Jung, Pil-Sup (Dept. of Otolaryngology, College of Medicine, Seoul National University) ;
  • Choi, Jin-Wook (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Kim, In-Young (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Lee, Kyu-Baek (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Min, Byoung-Goo (Dept. of Biomedical Engineering, College of Medicine, Seoul National University)
  • 발행 : 1993.11.12
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초록

In this article, we present and analyze the results of the three consecutive in vivo experiments of the LVAD to evaluate the function of the LVAD and the adverse effects on living animals. We applied the LVAD consecutively to three mongrel dogs and the circulation of the blood was assisted under the anesthesia. We used in general both the asynchronous mode and the synchronous mode to drive the LVAD. During the experiments we monitored the dogs with a polygraph to evaluate the function of the LVAD and the additional effects on the natural hearts. We also examined several clinical pathologic tests in order to see the effects of the LVAD to the red blood cells and the other internal organs. The dogs survived for two to there days. The LVAD assisted the circulatory system at the maximum assist flow rate of 3.0 1/min. Although the red blood cells of the dogs had mechanical damages by the LVAD to result in the hemolysis, the degree of the hemolysis was not so high and the damages caused by the hemolysis on the dogs were not serious. The myocardium of the first dog was gradually worsened and eventually failed. The damage of the myocardium was due to the asynchronous driving mode of the LVAD. The other organs did not have serious damages due to the application of the LVAD. The main purpose of this paper is to evaluate the results of the in vivo experiments of the LVAD and to find better ways to the application of the LVAD to human beings.

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