한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 1993년도 제1회 추계심포지움 and 제2회 생리분자과학연구센터워크숍
- /
- Pages.21-24
- /
- 1993
BIOADHESIVE GEL PREPARATIONS FOR RECTAL DRUG DELIVERY
초록
Many attempts have been made to use hydrogel as del ivory systems for various drug and vioactive materials to prolong and control their pharmacological activities. Rectal administration of drugs by using hydrogel bases, such as poloxamer ABA block copolymer (Pluronic F-127) gels, polyacrylic acid (Carbomer 934, 940, or 941) aqueous gels, and polyvilyl alcohol gels, have been reported on the preparation and potential suppository use of new gels(Eudragit L, Eudragit S, and Eudispert) that are block copolymers of methacrylic acid and methyl methacrylate. If) These hydrogel and xerogel preparations, especially Eudispert hv gels, show excellent staying and bioadhesive effects in the lower part of the rectum in rats and rabbits compared with those of polyethylene glycol (PEG)2000 and Witepsol H-15(or S-55) suppositories. Visual and optical microscopic observation of rectal membrances indicated no irritation or abnormality after administration of Eudispert hv tydrogel and xerogel.
키워드