대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference)
- 대한의용생체공학회 1991년도 춘계학술대회
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- Pages.82-85
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- 1991
CELL-MEDIATED IMMUNE PROCESSES AND CONTROL OF CANCER
- Lee, Kwon-Soon (Department of Electrical Engineering Dong-A University) ;
- Chung, Hyeng-Hwan (Department of Electrical Engineering Dong-A University)
- 발행 : 1991.05.15
초록
Cell kinetics and the chemical mass action principle formulate the basis of immune system dynamics which may be synthesized mathematically as cascades of bilinear systems which are connected by nonlinear nondynamical terms. In this manner, a model for cell-mediated immune response (CMI) to tumor antigens and debris is developed. We also consider parametric control variables relevant to the latest experimental data, i.e., sigmoidal dose-response relationship and Michaelis-Menten dynamics. The preliminary results show that the parametric control variable is important in the destruction of tumors. As well as that, the exacerbation theory is a good method for tumor treatment. Finally, tumor control as an application of immunotherapy is analyzed from the basis established above.
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