대한의용생체공학회:학술대회논문집 (Proceedings of the KOSOMBE Conference)

대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
권호 표지

혈장지 단백질에 대한 핵자기 공명 분광 분석

The proton nuclear magnetic resonance spectral analysis of human blood plasma lipoprotein

  • 송인찬 (서울 대학교 의과대학 의공학교실) ;
  • 강사욱 (서울 대학교 자연과학대학 미생물학과) ;
  • 김노경 (서울 대학교 의과대학 내과학교실) ;
  • 임정기 (서울 대학교 의과대학 방사선과학교실) ;
  • 민병구 (서울 대학교 의과대학 의공학교실)
  • Song, In-Chan (Dept. of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Kang, Sa-Ouk (Det. of Microbiology, College of Medicine, Seoul National University) ;
  • Kim, Noe-Kyeong (Dept. of Internal Medicine, College of Medicine, Seoul National University) ;
  • Im, Jung-Gi (Dept. of Radiology, College of Natural, Seoul National University) ;
  • Min, Byoung-Goo (Dept. of Biomedical Engineering, College of Medicine, Seoul National University)
  • 발행 : 1989.05.26
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초록

300 MHz proton NMR spectra of human blood plasma were analyzed by deconvolution of spectrum, and we compared its results with Fossel's test in normal (15 cases), liver cancer (14 cases) , and other cancer (14 cases) groups. This analysis had enabled us to obtain dynamic characteristics of each individual lipoprotein. As a result of deconvolution method, the VLDL and chylomicron intensity level were found to be elevated in the patients with liver cancer. Moment ratio values of $CH_2$ resonance in the raw spectrum were found to be higher than the normal group for patients with, malignant tumors other than liver cancer. These differences between the three groups could not be found in the conventional Fossel's test. We could simulate plasma spectra by addition of spectra of individual lipoproteins through deconvolution method. Further clinical trials in larger populations and additional biochemical method may shed new light on many of clinical and biochemical interests for knowing characteristics about lipoprotein not separated from blood and the background of Fossel test.

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