Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Cell-compatibility of physicochemically and biologically modified polymer surfaces

물리화학적 및 생물학적으로 표면개질된 고분자의 세포 적합성 연구

  • Lee, J.H. (Polymer Research Lab.3, Korea Research Institute of Chemical Technology) ;
  • Park, K.H. (Polymer Research Lab.3, Korea Research Institute of Chemical Technology) ;
  • Khang, G.S. (Polymer Research Lab.3, Korea Research Institute of Chemical Technology) ;
  • Lee, H.B. (Polymer Research Lab.3, Korea Research Institute of Chemical Technology) ;
  • Andrade, J.D. (Department of bioengineering, University of Utah)
  • 이진호 (한국화학연구소, 고분자제3연구실) ;
  • 박경희 (한국화학연구소, 고분자제3연구실) ;
  • 강길선 (한국화학연구소, 고분자제3연구실) ;
  • 이해방 (한국화학연구소, 고분자제3연구실) ;
  • Published : 1989.05.26
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Abstract

We have treated polymer surfaces such as polyethylene, polystyrene and polyester by various physicochemical and biological surface modification methods to be suitable for cell adhesion. The physicochemical methods we used were $O_2$ plasma discharge, corona discharge, sulfuric acid and chloric acid treatments. For the biological treatments, blood proteins such as plasma protein, serum protein and fibronectin were adsorbed onto the polymer surfaces. Chinese Hamster Ovary (CHO) cells were cultured on the surface-modified polymers and the cell-compatibility of those surfaces were compared. The chloric acid and fibronectin treatments were found to be the best methods of rendering the polymer surfaces adhesive for CHO cells.

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