고려인삼학회:학술대회논문집 (Proceedings of the Ginseng society Conference)

고려인삼학회 (The Korean Society of Ginseng)
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식물성 혈구 응집소(Phytohaemagglutinin)로 유도한 림파구 변형에 관한 인삼의 in vitro 및 in vivo효과

IN VITRO EFFECT OF PANAX GINSENG ON PHYTOHAEMAGGLUTININ-INDUCED LYMPHOCYTE TRANSFORMATION AND ITS IN VIVO EFFECT

  • Chong S.K.F. (Academic Department of Child Health, Queen Elizabeth Hospital for Children, and Department of Child Health, St. Bartholomew's Hospital) ;
  • Brown H.A. (Academic Department of Child Health, Queen Elizabeth Hospital for Children, and Department of Child Health, St. Bartholomew's Hospital) ;
  • Rimmer E. (Academic Department of Child Health, Queen Elizabeth Hospital for Children, and Department of Child Health, St. Bartholomew's Hospital) ;
  • Oberholzer V. (Academic Department of Child Health, Queen Elizabeth Hospital for Children, and Department of Child Health, St. Bartholomew's Hospital) ;
  • Hindocha P. (Academic Department of Child Health, Queen Elizabeth Hospital for Children, and Department of Child Health, St. Bartholomew's Hospital) ;
  • Walker-Smith J .A. (Academic Department of Child Health, Queen Elizabeth Hospital for Children, and Department of Child Health, St. Bartholomew's Hospital) ;
  • Carruthers L. (Academic Department of Child Health, Queen Elizabeth Hospital for Children, and Department of Child Health, St. Bartholomew's Hospital)
  • 발행 : 1984.09.01
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초록

Hydrocortisone과 ginseng 그리고 hydrocortisone과 ginseng의 혼합물이 phytohaemagglutinin (PHA-P)으로 유도한 모세혈관 림파구 변형에 미치는 영향을 검토하기 위하여 정상인 4명을 대상으로 연구하였다. 인삼의 농도를 0.16${\mu}g$/ml에서 1.60${\mu}g$/ml까지 증가시킴에 따라 PHA-P의 림파구 변형에 상관성이 있는 억제현상을 보였으며, hydrocortisone 500${\mu}g$/ml과 ginseng 0.8${\mu}/g$/ml을 동시 투여하였을 경우 각각 단일 물질 투여시 보다 상당한 PHA-P 변형의 억제효과를 나타냈다. 이는 인삼이 in vitro상에서 steroid와 유사한 효과를 갖고 있음을 시사해 주며, 면역에 hydrocortisone과 더불어 상당한 효과를 가지고 있다는 것을 보여주고 있다. in vivo상에서 6명의 정상인을 대상으로 PHA-P 변형에 대하여 인삼의 효과를 연구한 결과 4주에 이르러 상당한 억제효과가 관찰되었다.

The effect of hydrocortisone or Panax ginseng, and/or a combination of hydrocortisone and Panax ginseng on phytohaemagglutinin (PHA-P)-induced transformation of peripheral blood lymphocytes were studied in 4 normal healthy adult volunteers. Increasing concentrations of Panax ginseng 0.16-1.60${\mu}g$/ml caused a doserelated inhibition of PHA-P transformation of lymphocytes. A combination of 500${\mu}g$/ml hydrocortisone and 0.80${\mu}g$/ml Panax ginseng produced a greater suppression of PHA-P stimulation than either drug used alone. This suggests that Panax ginseng has a steroid-like effect in vitro, and may have a potentiating effect with hydrocortisone on T-cell mediated immunity. The in vivo effects of Panax ginseng were further studied in 6 healthy adult volunteers. PHA-P transformation studies were performed before and after Panax ginseng capsules were taken for 2 weeks and at a higher dosage at 4 weeks. Our results showed that in 3 subjects, there was significant inhibition of PHA-P transformation at 4 weeks.

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