A new derivative of phorbaketals isolated from a Marine Sponge Phorbas species

  • Hwang, Buyng-Su (Department of Oceanography, Kunsan National University) ;
  • Yang, Cao (Department of Oceanography, Kunsan National University) ;
  • Rho, Jung-Rae (Department of Oceanography, Kunsan National University)
  • Received : 2011.11.20
  • Accepted : 2011.12.13
  • Published : 2011.12.20


A new sesterterpenoid, phorbaketal derivative, was isolated from the marine sponge Phorbas species. Its planar structures was completely determined from a combination of extensive 1D and 2D NMR experiments and MS data, and also the stereochemistry on the chiral centers were established by the ROESY experiment and the comparison with the $^1H$ and $^{13}C$ chemical shifts of the known phorbaketal compounds. This compound 1 moderately showed cytotoxicity effect against hepatoma cancer HepG2 cell.


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